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Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels

Ana Gomis1, Sergio Soriano, Carlos Belmonte

  • 1Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández. Av. Ramón y Cajal s/n. 03550 Sant Joan d'Alacant, Alicante, Spain. agomis@umh.es

The Journal of Physiology
|October 4, 2008
PubMed
Summary

Transient receptor potential channel TRPC5 acts as an osmosensor, detecting changes in cell volume. This calcium channel is activated by osmotic pressure and membrane stretch, suggesting a role in sensory functions.

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