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Updated: Jun 29, 2026
10:13
A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
KRAS mutations: an old oncogene becomes a new predictive biomarker
Gregory J Riely1, Marc Ladanyi
1Thoracic Oncology Service, Department of Medicine, New York, New York, USA.
The Journal of Molecular Diagnostics : JMD
|October 4, 2008
Summary
A new assay detects KRAS mutations, which are emerging as key negative predictive biomarkers. This advancement aids in personalized medicine and treatment selection for patients.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- KRAS mutations are increasingly recognized as critical in cancer prognostication.
- Identifying these mutations aids in predicting treatment response.
Purpose of the Study:
- To highlight a novel assay for KRAS mutation detection.
- To emphasize the role of KRAS mutations as negative predictive biomarkers.
Main Methods:
- Development and validation of a novel assay.
- Focus on accurate detection of KRAS gene mutations.
Main Results:
- The novel assay demonstrates effective detection of KRAS mutations.
- KRAS mutations are confirmed as valuable negative predictive biomarkers.
Conclusions:
- The highlighted assay offers a new tool for clinical diagnostics.
- This assay supports personalized treatment strategies based on KRAS mutation status.
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