Related Experiment Video
Updated: Jun 29, 2026
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
The therapeutic phase I trial of the recombinant native HIV-1 Tat protein
Barbara Ensoli1, Valeria Fiorelli, Fabrizio Ensoli
1National AIDS Center, Istituto Superiore di Sanità, Rome, Italy. barbara.ensoli@iss.it
Abstract:
The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.
