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Updated: Jun 29, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Terbinafine-induced acute generalized exanthematous pustulosis
Summary
Terbinafine can trigger acute generalized exanthematous pustulosis (AGEP), a rare drug-induced skin reaction. Early diagnosis of AGEP is crucial for proper patient management and avoiding unnecessary treatments.
Area of Science:
- Dermatology
- Pharmacology
- Pathology
Background:
- Terbinafine is a widely used antifungal agent for dermatomycoses.
- Cutaneous adverse reactions, including pustular eruptions and psoriasis exacerbation, are known side effects.
- Acute generalized exanthematous pustulosis (AGEP) is an uncommon drug-induced pustular eruption.
Observation:
- Terbinafine has been associated with inducing and worsening psoriasis and AGEP.
- AGEP is characterized by sudden fever, widespread rash, and micropustules, often drug-induced.
- Histopathology reveals spongiotic pustules with neutrophils and dermal edema.
Findings:
- This study reports a case of terbinafine-induced AGEP.
- A review of literature confirms terbinafine's role in AGEP development.
- T-cells are implicated in the pathogenesis of drug-induced AGEP.
Implications:
- Early recognition of AGEP is vital to prevent misdiagnosis and inappropriate antibiotic use.
- Understanding terbinafine's potential to induce AGEP aids in clinical decision-making.
- Further research into AGEP pathogenesis may reveal targeted therapeutic strategies.
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