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Related Experiment Video

Updated: Jun 29, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Alopecia areata and autoimmunity.

M Grandolfo¹, A M Biscazzi, M Pipoli

¹Department of Internal Medicine, Immunology and Infective Diseases, Unit of Dermatology, University of Bari, Bari, Italy. maurograndolfo2@libero.it

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|October 4, 2008

Summary

This summary is machine-generated.

Alopecia areata (AA) is frequently linked to other autoimmune conditions. This study found that in 44% of patients, autoantibodies indicated underlying, often silent, organ diseases, particularly autoimmune thyroiditis.

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Area of Science:

Dermatology
Immunology
Endocrinology

Background:

Alopecia areata (AA) is an autoimmune condition affecting hair follicles.
The association between AA and other systemic autoimmune diseases requires further investigation.

Purpose of the Study:

To determine the prevalence of autoantibodies in patients with alopecia areata.
To explore the link between alopecia areata and underlying autoimmune pathologies.

Main Methods:

A panel of autoantibodies was assessed in 63 patients with various forms of alopecia areata.
Patients were categorized based on the extent of hair loss, including multiple patches, single patch, alopecia totalis, and alopecia universalis.

Main Results:

Autoantibodies were detected in 44% of patients (28 out of 63).
Thyroid-related autoantibodies (anti-thyroperoxidase, anti-thyroglobulin, antimicrosomal) and antinuclear antibodies were most common.
Autoimmune thyroiditis was diagnosed in 27% of cases (17 out of 63), often asymptomatic.

Conclusions:

Alopecia areata is often associated with other autoimmune diseases.
Assessing autoantibodies in AA patients can reveal silent organ pathologies in a significant percentage of cases.