[Endogenous psychoses with a first episode at the juvenile age: course and outcome (follow-up study)]

A clinical follow-up study (mean duration of the follow-up 16,8+/-6,4 years) of 278 patients with juvenile endogenous psychosis, episodic type (EPET, ICD-10 items F20.03, F20.23, F25), with the first episode in 1984-1995, demonstrated that the first five years was the period of most intensive manifestation of episodes (this period covered about a half of all recurrent episodes). At the time of follow-up, a favorable outcome was observed in 18,7% patients, a "relatively favorable" - in 33,8%, a "relatively poor" in 17,2%. An analysis of correlations of the course and outcome with the variant of the manifesting episode and some clinical and pathogenetic parameters allowed to single out a number of statistically significant criteria of clinical and social prognosis. The nosologic assessment at the time of follow-up showed that 76,2% of patients had schizophrenia (episodic-progressive - 61,1%, recurrent - 15,1%) and 23,8% - schizoaffective psychosis. A comparison of the present results with the results of the earlier study, allows to make a conclusion on the current pathomorphosis of EPET with the increase of favorable tendencies in the disease course and outcome, reduction of the progression rate and substantial decrease of cases of the transition to chronic stage.