Related Experiment Video
Updated: Jun 29, 2026
Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Catalytic alkynone generation by Sonogashira reaction and its application in three-component pyrimidine synthesis
Daniel M D'Souza1, Thomas J J Müller
1School of Chemistry, The University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, UK.
Abstract:
The Sonogashira alkynylation of acid chlorides can be efficiently conducted in less than an hour by performing the reaction in tetrahydrofuran as a solvent and in the presence of one stoichiometrically necessary equivalent of triethylamine as a base. This approach also opens new avenues for consecutive one-pot multicomponent reactions. As an example, the one-pot three-component pyrimidine synthesis illustrates the versatility of this modified Sonogashira protocol as an entry to diversity-oriented heterocycle synthesis in a one-pot fashion. The protocol can be completed within a few hours.
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