Application of liquid-based preparation to fine needle aspiration cytology in breast cancer
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Published on: September 29, 2009
Kyoko Komatsu1, Yoko Nakanishi, Toshimi Seki
1Pathology Laboratory, Nihon University Itabashi Hospital, Tokyo, Japan.
Objective:
To examine the performance of liquid-based cytology (LBC) in breast cytology to confirm the diagnosis of carcinoma.
Study Design:
Using cell clusters directly scratched from surgically removed tumor masses, we examined the immunocytochemistry, molecular biology and cytomorphology of the specimens.
Results:
LBC was very useful for gene analysis and evaluating the immunocytochemistry. The cytologic features of LBC were slightly different from those ofa conventional aspiration cytology smear.
Conclusion:
LBC is a promising method for improving the standardization ofpreparations in breast cytology, although care should be taken to account for its characteristic cytologic features. The quantitative analysis of HER-2 mRNA correlated with the results of immunohistochemistry.
