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Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
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Stress Prevention and Stress Management Techniques IV01:26

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Related Experiment Video

Updated: Jun 29, 2026

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

Malocclusion induces chronic stress.

Mitsuo Iinuma1, Yukiko Ichihashi, Yoko Hioki

  • 1Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Mizuho, Gifu 501-0296, Japan. iinuma@dent.asahi-u.ac.jp

Okajimas Folia Anatomica Japonica
|October 7, 2008
PubMed
Summary
This summary is machine-generated.

Occlusal disharmony accelerates hippocampal aging in mice, impairing spatial memory. Stress-induced hormonal changes and reduced glucocorticoid receptor expression contribute to cognitive decline.

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Published on: October 27, 2023

Area of Science:

  • Neuroscience
  • Aging Research
  • Stress Physiology

Background:

  • Occlusal disharmony is linked to stress responses.
  • Aging processes can affect cognitive functions, particularly spatial memory.
  • The hippocampus plays a crucial role in learning and memory.

Purpose of the Study:

  • To investigate the impact of occlusal disharmony on hippocampal function and stress markers in aging mice.
  • To explore the role of glucocorticoid receptors and stress hormones in age-related cognitive decline.

Main Methods:

  • Senescence-accelerated mice (SAMP8) were subjected to bite-raising to induce occlusal disharmony.
  • Plasma corticosterone levels, spatial learning (water maze), hippocampal neuron counts, and gene/protein expression (Fos, glucocorticoid receptors) were assessed.
  • Metyrapone, a glucocorticoid synthesis inhibitor, was used to examine its effects on stress and cognitive parameters.

Main Results:

  • Bite-raised aged mice exhibited elevated plasma corticosterone, impaired spatial memory, reduced Fos induction, and fewer hippocampal neurons compared to controls.
  • Glucocorticoid receptor (GR) and GR messenger ribonucleic acid (GRmRNA) expressions were significantly decreased in bite-raised mice.
  • Metyrapone pretreatment mitigated the increase in corticosterone, protected hippocampal neurons, and improved spatial learning.

Conclusions:

  • Occlusal disharmony may exacerbate hippocampal aging and cognitive deficits through stress pathways.
  • Stress-induced alterations in glucocorticoid signaling contribute to impaired spatial memory in aged mice.
  • Targeting stress responses could be a potential strategy to counteract age-related cognitive decline.