Related Experiment Video
Updated: Jun 29, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Reversible CO-induced chloride shuttling in Rh(I) tweezer complexes containing urea-functionalized hemilabile ligands
Hyojong Yoo1, Chad A Mirkin, Antonio G DiPasquale
1Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Abstract:
The urea moiety, which acts as a good hydrogen-bond donor, has been incorporated into a hemilabile phosphinoalkyl thioether ligand. Upon reaction of the ligand with a Rh(I) precursor, a tweezer complex with near-parallel planar urea moieties 2 forms. The host-guest interaction of 2 with Cl(-) has been characterized in solution and in the solid state. Cl(-) binding with the urea groups in 2 is retained under CO in nonpolar solvents to give a five-coordinate CO adduct 3. In polar solvents, CO binding to Rh(I) results in a Cl(-) shift from the urea host site to the Rh(I) metal center with a concomitant breaking of the Rh-S bonds. This is an unusual example of how two types of different interactions important in molecular recognition (ligand coordination to a metal and hydrogen bonding) can be regulated within one molecule through small-molecule coordination chemistry.
More Related Videos
10:39Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Published on: October 26, 2015
Related Concept Videos
Acid Halides to Amides: Aminolysis
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
E1 Reaction: Kinetics and Mechanism
Complexation Equilibria: The Chelate Effect
Acid Halides to Carboxylic Acids: Hydrolysis
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...