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Updated: Jun 29, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Progress in genetic studies of pain and analgesia
Michael L Lacroix-Fralish1, Jeffrey S Mogil
1Department of Psychology and Center for Research on Pain, McGill University, Montréal, Quebec, H3A1B1 Canada.
Abstract:
Interindividual variability in pain sensitivity and the response to analgesic manipulations remains a considerable clinical challenge as well as an area of intense scientific investigation. Techniques in this field have matured rapidly so that much relevant data have emerged only in the past few years. Our increasing understanding of the genetic mediation of these biological phenomena have nonetheless revealed their surprising complexity. This review provides a comprehensive picture and critical analysis of the field and its prospects.
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