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Related Experiment Video

Updated: Jun 29, 2026

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

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Pharmacotherapy in the extreme longevity.

G Fradà¹, E Bennati, E Cardillo

¹Geriatrics Unit, ASL No. 6, Ospedale dei Bianchi Vittorio Emanuele, Via Don Giovanni Colletto, I-90034 Corleone, Palermo, Italy. gfrada2003@libero.it

Archives of Gerontology and Geriatrics

|October 7, 2008

Summary

Centenarians often use multiple medications, but their daily drug consumption is lower than that of the general elderly population. Adverse drug events (ADE) were observed in 15.2% of these individuals.

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Area of Science:

Gerontology
Pharmacology
Public Health

Background:

Increased longevity leads to a higher prevalence of chronic-degenerative diseases and polypharmacy.
Understanding drug consumption patterns in the ultra-longevity population is crucial for managing health.
Centenarians represent a unique demographic for studying long-term health and medication use.

Purpose of the Study:

To evaluate the drug consumption patterns of centenarians.
To compare medication use with the clinical conditions of the ultra-longevity population.
To identify factors influencing drug use and adverse drug events (ADE) in centenarians.

Main Methods:

A study involving 602 centenarians.
Data collection included clinical history, objective examinations, and clinico-functional evaluations.
Pharmacological anamnesis was obtained from 555 participants.

Main Results:

95% of centenarians used regular pharmacological therapy, with a mean daily consumption of 2.7 drugs.
20.7% of centenarians were in good clinical condition; 75.7% of these used 1-3 drugs daily.
Adverse drug events (ADE) occurred in 15.2% of participants, often associated with polypharmacy.

Conclusions:

Mean daily drug consumption in centenarians was lower than in the general elderly population.
Factors such as past health, physician attention, and caregiver involvement may influence medication use.
Managing polypharmacy and ADE is essential even in the ultra-longevity demographic.