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Updated: Jun 29, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Lupus mastitis associated with severe systemic erythematosus lupus]
A-R Guerre1, F Pelletier, F Aubin
1Service de dermatologie, CHU Saint-Jacques, 2, place Saint-Jacques, 25030 Besançon cedex, France.
La Revue De Medecine Interne
|October 7, 2008
Summary
Systemic lupus erythematosus can manifest as lupus mastitis, a rare form of lupus panniculitis presenting as breast nodules and skin lesions. Antimalarial drugs are the recommended first-line treatment for this condition.
Area of Science:
- Dermatology
- Rheumatology
- Oncology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Lupus panniculitis is a rare manifestation of SLE affecting subcutaneous fat.
- Lupus mastitis, a specific form of lupus panniculitis, involves the breast tissue.
Observation:
- A 46-year-old woman with SLE presented with deep breast nodules and superficial erythematosus/keratotic skin lesions.
- Neoplasia was excluded through X-ray and echographic imaging.
- Subcutaneous and skin biopsies confirmed lupus mastitis.
Findings:
- Lupus mastitis is an uncommon presentation of lupus panniculitis, often associated with SLE.
- The condition requires thorough investigation, including deep biopsies, to rule out breast neoplasia.
- Antimalarial medications are the primary therapeutic approach.
Implications:
- This case highlights the importance of considering lupus mastitis in SLE patients with breast abnormalities.
- Accurate diagnosis through biopsy is crucial to differentiate from breast cancer.
- Early treatment with antimalarials can effectively manage lupus mastitis.
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