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Updated: Jun 29, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Nitric oxide and interlukin-6 levels in intellectual disability adults with epilepsy
Eli Carmeli1, Reut Beiker, Mohammed Morad
1Department of Physical Therapy, Sackler Faculty of Medicine, Stanley, Steyer School of Health Professions, Tel Aviv University, Ramat Aviv 69978, Israel. elie@post.tau.ac.il
Abstract:
Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. The role of NO and IL-6 in the neuropathogenesis of brain seizures is still questionable. In order to evaluate the role of NO and IL-6 in neurological disorders such as seizures, we investigated 19 adults with intellectual disability (ID) who suffer from epilepsy and treated for convulsions. NO metabolites (NOx) and IL-6 levels in serum obtained after night-sleep were significantly high among ID individuals diagnosed with epilepsy versus ID people without epilepsy. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Consequently, we suggest that professionals consider chemical inhibitors that might be helpful against the function of NO and IL-6.
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