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Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical
J B Kuks1, H J Oosterhuis, P C Limburg
1Department of Neurology, University Hospital Groningen, The Netherlands.
Journal of Autoimmunity
|April 1, 1991
Abstract:
Clinical course and changes in serum levels of antibodies to the acetylcholine receptor (a-AChR) were followed in 82 patients with myasthenia gravis during a period of 1-8 years after thymectomy. Decrease in a-AChR immediately after thymectomy was influenced by changes in a total IgG. Immunosuppressive medication affected serum a-AChR at all points of time. In a subgroup of 41 patients without thymoma who had no immunosuppressive drugs, there was a steady decrease in a-AChR concomitant with clinical improvement from 6 weeks after thymectomy.