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Effects of tomato extract on oxidative stress induced toxicity in different organs of rats
Akram Jamshidzadeh1, Maryam Baghban, Negar Azarpira
1Department of Pharmacology and Toxicology, Shiraz University of Medical Sciences, Shiraz, Fars 71345-1583, Iran.
Abstract:
Tomato products containing lycopene are believed to be associated with decreased risk of chronic diseases including cancer, and its effects are suggested to be due to antioxidant effect of lycopene. The aim of this research was to study the effects of tomato extract on acetaminophen (APAP), amiodarone (ADN) and cyclosporine A (CsA)-induced liver, lung and kidney toxicity, respectively. Previous studies have shown that free radical reactions may play important roles in toxicity of these drugs. Rats received a single dose of APAP (750mg/kg, i.p.) before treatment with tomato extract (5mg/kg, oral) for seven consecutive days, ADN (100mg/kg, i.p.) plus tomato extract (5mg/kg, oral) for 10 consecutive days, or CsA (250mg/kg, i.p.) plus tomato extract (5mg/kg, oral) for 14 consecutive days. At the end of each treatment, the animals were sacrificed and the related organ tissues were collected for biochemical and histopathological examinations. Simultaneous treatment of tomato extract ameliorated tissue damage, biochemical indices, and oxidative stress parameters against APAP-induced acute hepatotoxicity, but had less beneficial effects on ADN-induced lung toxicity and little effect against CsA-induced nephrotoxicity. Therefore, tomato products may be beneficial for the prevention and therapy of toxicity induced by ADN and APAP.
Insights
Tomato extract, rich in lycopene, shows promise in protecting against acetaminophen-induced liver toxicity. However, its benefits are less pronounced for amiodarone-induced lung and cyclosporine A-induced kidney damage.
Area of Science:
- Toxicology
- Nutritional Science
- Pharmacology
Background:
- Lycopene, a compound in tomato products, is linked to reduced chronic disease risk due to its antioxidant properties.
- Drug-induced organ toxicities, such as those caused by acetaminophen, amiodarone, and cyclosporine A, are often associated with free radical damage.
Purpose of the Study:
- To investigate the protective effects of tomato extract against liver, lung, and kidney toxicity induced by specific drugs.
- To evaluate the efficacy of tomato extract in mitigating drug-induced oxidative stress and tissue damage.
Main Methods:
- Rats were administered acetaminophen, amiodarone, or cyclosporine A, followed by concurrent treatment with tomato extract.
- Organ tissues (liver, lung, kidney) were collected for biochemical and histopathological analysis to assess toxicity and oxidative stress markers.
Main Results:
- Tomato extract significantly ameliorated liver damage and oxidative stress markers in acetaminophen-induced hepatotoxicity.
- The protective effects were less pronounced in amiodarone-induced lung toxicity and minimal in cyclosporine A-induced kidney toxicity.
Conclusions:
- Tomato products, owing to their lycopene content, may be beneficial in preventing and treating acetaminophen-induced liver toxicity.
- Further research is needed to fully understand the therapeutic potential for amiodarone and cyclosporine A-induced toxicities.