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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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Published on: August 28, 2014

Angiogenesis and plastic surgery.

Mohammed Ali Akhavani1, Branavan Sivakumar, Ewa M Paleolog

  • 1Restoration of Appearance of Function Trust, Northwood, UK. mo@doctors.org.uk

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|October 7, 2008
PubMed
Summary
This summary is machine-generated.

Angiogenesis, the formation of new blood vessels, is crucial for healing in plastic surgery. Controlling this process can significantly improve outcomes in flap survival, nerve regeneration, and wound healing.

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Area of Science:

  • Physiology
  • Vascular Biology
  • Regenerative Medicine

Background:

  • Angiogenesis is a fundamental physiological process.
  • It plays a critical role in both normal and pathological conditions.
  • Understanding angiogenesis is vital for advancements in reconstructive surgery.

Purpose of the Study:

  • To summarize current knowledge on angiogenesis regulation.
  • To explore the role of disordered angiogenesis in plastic surgery pathologies.
  • To provide an overview of recent advances in angiogenesis relevant to plastic surgery.

Main Methods:

  • Literature review of angiogenesis physiology and pathology.
  • Analysis of angiogenesis control mechanisms.
  • Examination of clinical applications in plastic surgery.

Main Results:

  • Angiogenesis is a key factor in the success of reconstructive surgery procedures.
  • Dysregulation of angiogenesis contributes to various pathological states relevant to plastic surgery.
  • Recent advances offer potential therapeutic benefits for controlling angiogenesis.

Conclusions:

  • Controlling angiogenesis holds significant therapeutic potential in plastic and reconstructive surgery.
  • This review highlights advances in understanding and manipulating angiogenesis for improved surgical outcomes.
  • Applications include enhanced flap survival, tendon and nerve regeneration, fracture healing, and ulcer treatment.