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Nck-1 interacts with PKR and modulates its activation by dsRNA

Eric Cardin1, Louise Larose

  • 1Experimental Medicine Department, Polypeptide Laboratory, McGill University, Montreal, Que, Canada.

Biochemical and Biophysical Research Communications
|October 7, 2008
PubMed
Summary

The adaptor protein Nck-1 acts as a novel regulator of the double-stranded RNA (dsRNA)-activated protein kinase PKR. Nck-1 prevents PKR activation by dsRNA, thereby limiting protein synthesis inhibition and cell death.

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