Related Experiment Video
Updated: Jun 29, 2026

Standardized Method for High-throughput Sterilization of Arabidopsis Seeds
Published on: October 17, 2017
Grouped nucleotide polymorphism: a major contributor to genetic variation in Arabidopsis
Jianchang Du1, Tingting Gu, Hao Tian
1State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
Abstract:
While information for single nucleotide polymorphism is accumulating in many organisms, little is known about the magnitude and the occurrence of nucleotide dimorphism or higher order structural polymorphisms (grouped nucleotide polymorphisms or GNPs). To address these questions, we systematically investigated the genetic variations of 996 loci in 96 Arabidopsis accessions. Our data suggest that GNP loci are highly frequent in the genomes (40.4% of 996 loci), and that 66.7% of genetic variation in 996 loci is attributed to GNPs. The frequency distribution and the linkage analysis of GNP loci demonstrate that GNPs occurred randomly, locally, ceaselessly and independently in general, although they are particularly abundant in the region near centromeres. The age distribution of GNP loci shows that the majority of these loci are under a transient phase of neutral evolution. The characteristics of GNPs imply that a molecular isolation exists in GNP loci, and most likely the indels caused isolation, which could explain how GNPs are generated and maintained.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Overview of Transposition and Recombination
Genetic Variation
Genes exist in different versions called alleles, which...
Principles of Pharmacogenetics: Types of Genetic Variants
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Genetics of Speciation

