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Published on: February 3, 2012
[Chronic viral C hepatitis associated with primary biliary cirrhosis. Report of two cases]
1Service de gastro-entérologie, hôpital Charles-Nicolle, 1007 Tunis, Tunisie. leilamouelhi@yahoo.fr
Abstract:
Chronic viral hepatitis C is often associated with various autoimmune disorders. We report two patients infected by genotype 1b hepatitis C virus associated with primary biliary cirrhosis. These patients had anicteric cholestasis associated with cytolysis and positivity of M2 antimitochondrial antibodies at a titre of 1/200. Liver biopsy revealed chronic hepatitis in one case and histological pattern of primary biliary cirrhosis in the other. One patient was treated by antiviral therapy; the other only by ursodesoxycholic acid because of the association with hemolytic anemia. Association between primary biliary cirrhosis and chronic viral hepatitis C is uncommon and associated with diagnostic and therapeutic challenges.
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