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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: Jun 29, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

TB database: an integrated platform for tuberculosis research.

T B K Reddy1, Robert Riley, Farrell Wymore

  • 1Department of Biochemistry, Stanford University, CA 94305, USA. tbreddy@stanford.edu

Nucleic Acids Research
|October 7, 2008
PubMed
Summary
This summary is machine-generated.

The Tuberculosis Database (TBDB) centralizes genomic and experimental data for Mycobacterium tuberculosis, aiding the development of new tuberculosis drugs, vaccines, and biomarkers. This resource facilitates TB research by integrating diverse datasets and analysis tools.

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Related Experiment Videos

Last Updated: Jun 29, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
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A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Tuberculosis (TB) control is challenged by lengthy drug regimens, an inefficient vaccine, and lack of clinical biomarkers.
  • Genomic data for TB research is fragmented, hindering progress due to the absence of a centralized repository.
  • Effective TB control requires integrated genomic and experimental data for analysis and discovery.

Purpose of the Study:

  • To establish the Tuberculosis Database (TBDB) as a central repository for TB genomic and experimental data.
  • To facilitate the discovery and development of novel TB drugs, vaccines, and biomarkers.
  • To provide researchers with integrated access to TB data and analysis tools.

Main Methods:

  • Integrated diverse genomic datasets, including genome sequences and annotations for 28 Mycobacterium tuberculosis strains.
  • Collected and stored pre- and post-publication gene-expression data for M. tuberculosis and related bacteria.
  • Provided access to comparative genomics and microarray analysis software, hosting data for nearly 1500 TB microarrays.

Main Results:

  • TBDB houses genome sequence data and annotations for 28 M. tuberculosis strains and related bacteria.
  • The database stores extensive gene-expression data and hosts data for over 1700 public microarrays.
  • TBDB offers integrated analysis tools for comparative genomics and microarray data.

Conclusions:

  • TBDB serves as a unique discovery platform for tuberculosis research by integrating M. tuberculosis genome annotation and gene-expression data.
  • The centralized database and analysis tools accelerate the development of new TB diagnostics and therapeutics.
  • TBDB enhances TB research by providing readily accessible and analyzable genomic and experimental data.