Related Experiment Video
Updated: Jun 29, 2026

In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles
Amanda J LeBlanc1, Robert D Shipley, Lori S Kang
1Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, P.O. Box 9105, 1 Medical Center Dr., West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Abstract:
Impairment of flow-induced vasodilation in coronary resistance arterioles may contribute to the decline in coronary vasodilatory reserve that occurs with advancing age. This study investigated the effects of age on flow-induced signaling and activation of nitric oxide (NO)-mediated vasodilation in coronary resistance arterioles. Coronary arterioles were isolated from young (approximately 6 mo) and old (approximately 24 mo) male Fischer-344 rats to assess vasodilation to flow, vascular endothelial growth factor (VEGF), and ACh. Flow- and VEGF-induced vasodilation of coronary arterioles was impaired with age (P
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Coronary Artery Disease II: Pathophysiology

