Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Preventive Healthcare Services

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.

Diagnostic and Statistical Manual of Mental Disorders (DSM)

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A randomized controlled trial to evaluate innovative decision support in the context of fall prevention.

NPJ digital medicine·2025

Same author

Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Attention Bias Modification Training in remitted recurrently depressed patients with 1.5 year follow-up.

BMC psychiatry·2025

Same author

Anhedonia as a Transdiagnostic Symptom Across Psychological Disorders: A Network Approach.

Focus (American Psychiatric Publishing)·2025

Same author

Polyunsaturated fatty acids changes during electroconvulsive therapy in major depressive disorder.

Journal of psychiatric research·2023

Same author

Anhedonia as a transdiagnostic symptom across psychological disorders: a network approach.

Psychological medicine·2022

Same author

Negative memory bias as a transdiagnostic cognitive marker for depression symptom severity.

Journal of affective disorders·2020

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Patients' view on screening for depression in general practice.

K A Wittkampf¹, M van Zwieten, F Th Smits

¹Department of Psychiatry, Programme for Mood Disorders, University of Amsterdam and Jellinenk Mentrum Mental Health Care, Amsterdam, The Netherlands. k.a.wittkampf@amc.uva.nl

Family Practice

|October 7, 2008

Summary

Many patients screened positive for depression but resisted diagnosis due to stigma and doubts about treatment effectiveness. Understanding patient perspectives is crucial before offering depression treatment.

Related Experiment Videos

Last Updated: Jun 29, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Mental Health
General Practice
Qualitative Research

Background:

Depression is often unrecognized in general practice, leading to 'hidden morbidity'.
Screening programs for depression aim to improve detection, but results on patient outcomes are inconsistent.
Patient acceptance of depression diagnosis and subsequent treatment remains a challenge.

Purpose of the Study:

To explore the perspectives of patients who screened positive for depression in a general practice setting.
To understand patient acceptance of a depression diagnosis following screening.
To identify factors influencing patient willingness to engage with depression treatment.

Main Methods:

A qualitative study involving semi-structured in-depth interviews.
17 adult patients diagnosed with major depressive disorder via a screening program in Dutch general practices participated.
Interview transcripts were independently analyzed by two researchers.

Main Results:

All interviewed patients appreciated the active screening approach.
While 15 patients recognized their depressive symptoms, 9 rejected the diagnosis.
Reasons for non-acceptance included fear of stigmatization, skepticism about labeling, viewing symptoms as normal reactions to adversity, and doubts about treatment necessity/effectiveness.

Conclusions:

Some patients identified through depression screening programs resist the diagnosis.
Factors such as stigma, perceived normality of symptoms, and treatment skepticism contribute to this resistance.
Eliciting patient views on depression is recommended before diagnosis and treatment initiation in screening contexts.