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Modulation of elastase-like activity in fibroblasts stimulated with elastin peptides
J Gmiński1, L Weglarz, M Drózdz
1Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Biochemical Medicine and Metabolic Biology
|April 1, 1991
Abstract:
Elastin-derived peptides, kappa-elastin, prepared by chemical degradation of insoluble elastin from bovine ligamentum nuchae, were shown to increase the elastase-like activity in the culture medium and cell fractions in fibroblasts. Preincubation of cells with nifedipine (calcium channel blocker) and trifluoperazine (calmodulin antagonist) induced a decrease in the activities of the enzyme under study. These data suggest the possibility of pharmacological modulation of the biological effects induced by elastin-derived peptides.