Related Experiment Video
Updated: Jun 29, 2026

Intraductal Delivery to the Rabbit Mammary Gland
Published on: March 9, 2017
Lobular and ductal intraepithelial neoplasia
1Department of Pathology, Yale University School of Medicine, Lauder Hall 222, 310 Cedar Str., New Haven, CT 06510, USA. fattaneh.tavassoli@yale.edu
Abstract:
Lobular and ductal intraepithelial neoplasias reflect proliferations of immunophenotypically variable, biologically and morphologically diverse cells with a potential, not always realized, for progression to carcinoma by breaking through the barriers of the myoepithelial cell layer and basement membrane, ultimately invading the stroma. Starting with the lobular and then the ductal proliferations, this review will address the evolution of our understanding of these lesions; the problems associated with the conventional terminology of ductal hyperplasia, atypical hyperplasia, and carcinoma in situ; and reasons for and advantages of the intraepithelial neoplasia terminology.
Related Concept Videos
Classification of Epithelial Tissues: Glandular Epithelium
Multicellular glands are formed during early development when epithelial budding...
Cellular Adaptation IV: Dysplasia and Metaplasia
The Mammary Glands
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Classification of Epithelial Tissues: Overview
Based on the number of cell layers,...
lncRNA - Long Non-coding RNAs
Exocrine Glands: Unicellular and Multicellular Glands

