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Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

Dynamic cardiomyoplasty using artificial muscle.

Yasuyuki Suzuki¹, Kazuyuki Daitoku, Masahito Minakawa

¹Department of Thoracic and Cardiovascular Surgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan. ysuzuki@cc.hirosaki-u.ac.jp

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs

|October 7, 2008

Summary

This summary is machine-generated.

Artificial muscles made from BioMetal fiber show promise as a cardiac support device, potentially overcoming limitations of traditional dynamic cardiomyoplasty due to skeletal muscle fatigue.

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Area of Science:

Biomedical Engineering
Materials Science

Background:

Dynamic cardiomyoplasty using latissimus dorsi muscle was a treatment for congestive heart failure.
Skeletal muscle fatigue limits the long-term efficacy of this procedure.

Purpose of the Study:

To develop and test an artificial muscle as a potential cardiac support device.
To evaluate the feasibility of using BioMetal fiber for dynamic cardiomyoplasty.

Main Methods:

Constructed a 4 x 12-cm artificial muscle using 8 BioMetal fibers.
Developed a simulation circuit with a soft bag, valves, and reservoir.
Electrically activated the artificial muscle to assess its performance.

Main Results:

A single BioMetal fiber demonstrated a maximal generative force of 30 g and 50% exercise variation.
The artificial muscle contracted in 0.5 s, generating a peak pressure of 10 mmHg within the simulated cardiac sac.
The device operated at 220 mA per fiber with a 9 V electrical supply.

Conclusions:

Artificial muscles using BioMetal fiber show potential as a cardiac assistance device.
This technology could offer an alternative to overcome the limitations of skeletal muscle fatigue in dynamic cardiomyoplasty.
Further research is needed to improve the speed and movement dynamics of the artificial muscle.