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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jun 29, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Orbital melanocytoma.

Alka Mary Mathai1, Ramadas Naik, Muktha R Pai

  • 1Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India. alka977@gmail.com

Orbit (Amsterdam, Netherlands)
|October 7, 2008
PubMed
Summary
This summary is machine-generated.

This case report details a rare instance of an intermediate grade meningeal melanocytoma, an orbital tumor, presenting as a recurrent mass. Early diagnosis and aggressive management are crucial for this rare orbital tumor.

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Area of Science:

  • Neuro-oncology
  • Ophthalmology
  • Pathology

Background:

  • Melanocytomas are rare, pigmented central nervous system tumors, typically found in the posterior cranial fossa or spinal region.
  • Orbital melanocytomas are exceptionally rare, with limited documented cases.

Observation:

  • A 40-year-old male presented with a 4-year history of progressive proptosis due to a right orbital mass.
  • Imaging revealed an intraconal orbital mass; biopsy confirmed a highly cellular, infiltrating melanocytic neoplasm.

Findings:

  • Histopathology and immunohistochemistry (S-100, HMB-45) confirmed the diagnosis of intermediate grade meningeal melanocytoma.
  • The tumor exhibited local infiltration, suggesting a more aggressive behavior than typical melanocytomas.

Implications:

  • Recurrent intermediate grade orbital melanocytomas require differentiation from similar tumors.
  • Intracranial extension necessitates aggressive management due to proximity to visual pathways.