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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Cardiac biomarkers and chronic renal diseases

I Valocikova1, B Kristofova, G Valocik

  • 11st Department of Internal Medicine, University Hospital, Safarikiensis University, Kosice, Slovakia. irosochova@hotmail.com

Bratislavske Lekarske Listy
|October 8, 2008
PubMed

Insights

Patients with chronic kidney disease face higher risks of cardiovascular events. Biomarkers like C-reactive protein and troponin can predict mortality in these patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Accelerated atherosclerosis is common in chronic renal failure, increasing cardiovascular disease risk.
  • A significant link exists between kidney disease and cardiac conditions, leading to higher morbidity and mortality.
  • Biomarkers are crucial for predicting outcomes in patients with kidney disease.

Purpose of the Study:

  • To evaluate individual biomarkers for predicting outcomes in patients with chronic kidney disease.
  • To identify key predictors of cardiovascular and all-cause mortality in end-stage renal disease.

Main Methods:

  • Evaluation of various individual biomarkers.
  • Analysis of markers for myocardial necrosis (troponin T/I).
  • Assessment of heart failure markers (B-type natriuretic peptide), inflammation (C-reactive protein), and nitric oxide inhibition (asymmetric dimethylarginine).

Main Results:

  • Increased concentrations of C-reactive protein, B-type natriuretic peptide, asymmetric dimethylarginine, and troponin were observed.
  • These elevated markers predict a high risk of cardiovascular mortality.
  • The identified biomarkers also predict mortality from other causes in chronic renal failure patients.

Conclusions:

  • Specific biomarkers effectively predict adverse outcomes in patients with chronic kidney disease.
  • Monitoring these biomarkers can help identify high-risk individuals with end-stage renal disease.
  • Early identification of risk through biomarkers may inform clinical management strategies.

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