Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of Ki-67 and p53 in meningiomas.

Neoplasma·2013
Same author

Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimer's disease patients--a pilot study.

Analytical and bioanalytical chemistry·2010
Same author

Role of haematological testing: ratio values of circulating platelet aggregates in visual field loss associated with pseudoexfoliation glaucoma.

Bratislavske lekarske listy·2010
Same author

Gait apraxia.

Bratislavske lekarske listy·2010
Same author

Alzheimer's disease patients: quality of life in the Republic of Croatia.

Bratislavske lekarske listy·2010
Same author

Clinical manifestations of neurosarcoidosis.

Bratislavske lekarske listy·2009
Same journal

Imunological aspects of kidney retransplantation.

Bratislavske lekarske listy·2024
Same journal

The effect of lengthening of the percutaneous implant in the surgical treatment of Th-L ankylosed spine fractures: 4 segment fixation versus 5 to 8 segment fixation.

Bratislavske lekarske listy·2024
Same journal

Prostate cancer in Slovakia: last decade overview.

Bratislavske lekarske listy·2024
Same journal

Cancer epidemiology in Slovakia.

Bratislavske lekarske listy·2024
Same journal

Peculiarities of nutritional support in patients with neoplasms of the hepatopancreatoduodenal zone as a component of intensive therapy in the postoperative period.

Bratislavske lekarske listy·2024
Same journal

A comparative review of coronary computed tomography angiography and myocardial perfusion imaging.

Bratislavske lekarske listy·2024
See all related articles

Related Experiment Video

Updated: Jun 29, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Spondylodiscitis.

M Titlic1, Z Josipovic-Jelic

  • 1Department of Neurology, University Hospital Split, Split, Croatia. marina.titlic@gmail.com

Bratislavske Lekarske Listy
|October 8, 2008
PubMed
Summary
This summary is machine-generated.

Spondylodiscitis, a common complication of infections in immunocompromised patients, is often caused by staphylococci or tuberculosis. Diagnosis relies on MRI, biopsy, and microbiological tests, with PCR increasingly used to identify causative organisms.

More Related Videos

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Related Experiment Videos

Last Updated: Jun 29, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Radiology

Background:

  • Spondylodiscitis is a frequent complication of sepsis or local infections, particularly in immunocompromised individuals.
  • It commonly affects patients with malignant diseases, ongoing infections, or those undergoing immunosuppressive therapy for organ transplantation.
  • Identifying the causative agent is crucial for effective treatment.

Purpose of the Study:

  • To review the existing literature on the causes of spondylodiscitis.
  • To highlight the spectrum of microorganisms responsible for this condition.
  • To emphasize the importance of considering diverse etiological agents in diagnosis and treatment.

Main Methods:

  • Literature review of existing studies on spondylodiscitis.
  • Analysis of reported causative organisms and diagnostic approaches.
  • Focus on microbiological and molecular diagnostic techniques.

Main Results:

  • Staphylococci and Mycobacterium tuberculosis are identified as the primary causative organisms.
  • A wide range of bacteria, fungi, and zoonotic agents can also lead to spondylodiscitis.
  • Polymerase Chain Reaction (PCR) is increasingly utilized for pathogen detection.

Conclusions:

  • Spondylodiscitis has diverse etiologies, necessitating a broad diagnostic approach.
  • Accurate identification of causative agents, including bacteria, fungi, and zoonoses, is essential.
  • Advanced methods like PCR aid in timely and precise diagnosis, guiding appropriate patient management.