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Updated: Jun 29, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
[Study on absorption kinetics of astragaloside IV in rats intestines]
Huai-Peng Huang1, Cai-Xia Liu, Yan-Ling Li
1Hebei Ping'an Healthy Group Co. Ltd., Shijiazhuang 050021, China. huang71526@163.com
Objective:
To investigate the mechanisms of intestine absorption of astragaloside IV in rat.
Method:
The K(a) and P(app) of astragaloside IV was investigated using single-pass intestinal perfusion technique in rats. HPLC was used to determine the concentration of astragaloside IV. The effect of absorption site, drug concentration and the inhibitors of P-glycoproteon on the absorption had been studied.
Result:
By the testing of the statistics, the K(a) and the P(app) values of the duodenum, jejunum, ileum, colonic had significant differences (P < 0.05). The concentration from 20-80 mg x L(-1) had no distinctive effect on the K(a) and P(app) of small intestine. The inhibitors of P-glycoproteon had no distinctive effect on the absorption of small intestine.
Conclusion:
Astragaloside IV is absorbed by typical passive diffusion mechanism.
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