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[Progress on antineoplastic constituents derived from polypore fungi]
Gang Ren1, Chang-xin Zhou, Cang-qian Xiao
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Summary
Polypore fungi contain potent antitumor compounds like polysaccharides and terpenoids. These natural compounds show significant potential for developing novel anti-cancer drugs.
Area of Science:
- Mycology
- Pharmacology
- Natural Products Chemistry
Context:
- Polypore fungi are recognized for their diverse pharmacological properties.
- There is a growing interest in identifying and utilizing natural compounds for cancer treatment.
Purpose:
- To review and categorize the antitumor active constituents derived from polypore fungi.
- To discuss the potential of polypore fungi in the development of new anti-cancer drugs.
Summary:
- This review consolidates research on high molecular weight compounds (polysaccharides, glycopeptides, glycoproteins, lectins) and low molecular weight compounds (terpenoids, steroids, phenolics, benzopyranones) from polypore fungi with antitumor activity.
- The study highlights various chemical classes of bioactive compounds isolated from these fungi.
Impact:
- Provides a comprehensive overview of polypore-derived antitumor agents for researchers.
- Suggests the significant potential of polypore fungi as a source for novel anti-cancer drug discovery and development.
