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Published on: October 1, 2017
Partially polyurethane-covered stent for cerebral aneurysm treatment
Hussain S Rangwala1,2, Ciprian N Ionita1,3,4, Stephen Rudin1,3,4,2,5
1Toshiba Stroke Research Center, State University of New York at Buffalo, Buffalo, New York.
Summary
Partially polyurethane-covered stents (PPCS) effectively modulate blood flow in cerebral aneurysms. This innovative stent design preserves vessel integrity while promoting healing and reducing aneurysm risks.
Area of Science:
- Biomedical Engineering
- Medical Devices
- Cardiovascular Research
Background:
- Cerebral aneurysms pose significant risks, necessitating advanced treatment strategies.
- Current treatments may have limitations in preserving blood flow dynamics and vessel patency.
- Partially covered stents offer a potential solution for targeted aneurysm treatment.
Purpose of the Study:
- To evaluate the efficacy of partially polyurethane-covered stents (PPCS) in modulating blood flow within patient-specific cerebral aneurysm models.
- To assess the biocompatibility and mechanical integrity of the polyurethane membrane on the stent.
- To investigate the impact of PPCS placement on hemodynamic parameters within the aneurysm.
Main Methods:
- Utilized patient-specific aneurysm phantoms (PSAP) to simulate cerebral aneurysm conditions.
- Assessed polyurethane membrane biocompatibility using contact angle measurements for critical surface tension (CST).
- Evaluated stent mechanical properties (flexibility, stiffness) and flow modulation using time density curves (TDCs) before and after PPCS implantation.
Main Results:
- PPCS significantly altered aneurysm inflow dynamics, acting as effective flow modulators.
- Polyurethane membrane exhibited thromboresistant properties (CST 20-30 mN/m) and maintained structural integrity without delamination.
- Stent mechanical properties remained largely unchanged after asymmetric PU film application.
- Placement orientation influenced flow modulation, demonstrating targeted therapeutic potential.
Conclusions:
- Partially polyurethane-covered stents are a promising technology for cerebral aneurysm treatment.
- PPCS demonstrate effective hemodynamic modulation and favorable biocompatibility, preserving essential perforator vessels.
- This approach offers a scaffold for vessel repair while managing aneurysm hemodynamics.
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