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Hypertension and circulating mRNA for 11beta-hydroxysteroid dehydrogenase type II
S Agalou1, A N Butt, Phil Chowienczyk
1Department of Chemical Pathology, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
Abstract:
Circulating DNA and mRNA for 11beta-hydoxysteroid dehydrogenase (HSD) type II were measured in patients with hypertension and in healthy subjects. DNA and RNA levels in hypertensive patients and controls were quantified using real-time RT-PCR. Messenger RNA for 11beta-HSD type II was significantly lower in the hypertensive patients (median: 0.18) (P= 0.032) than in healthy subjects (median: 0.42). Plasma DNA was also significantly lower (P= 0.016) in hypertension. It is suggested that measurement of mRNA for 11beta-HSD type II in hypertension may identify subjects who may be salt-sensitive.
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