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The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol

Lis Neubeck1, Julie Redfern, Tom Briffa

  • 1Faculty of Medicine, University of Sydney, Sydney, Australia. lneubeck@med.usyd.edu.au

BMC Cardiovascular Disorders
|October 8, 2008
PubMed

Insights

The CHOICE program, a secondary prevention strategy for coronary heart disease (CHD) survivors, is being tested for replication across multiple sites. This study evaluates if extended reinforcement improves risk factor modification in acute coronary syndrome (ACS) patients.

Area of Science:

  • Cardiology
  • Public Health
  • Preventive Medicine

Background:

  • Coronary heart disease (CHD) poses significant mortality and morbidity risks.
  • Few acute coronary syndrome (ACS) survivors engage in effective secondary prevention.
  • The CHOICE program has demonstrated prior success in risk factor modification.

Purpose of the Study:

  • To assess the replicability of the CHOICE program across multiple centers.
  • To determine if extended reinforcement in the CHOICE program enhances risk factor modification.
  • To evaluate the long-term effectiveness of a modular secondary prevention strategy for CHD.

Main Methods:

  • A multi-center, randomized controlled trial design.
  • Participants not accessing standard cardiac rehabilitation will be randomized to a 3-month CHOICE program or a 30-month CHOICE-plus program.
  • Both groups receive individualized risk factor modules with telephone follow-up; CHOICE-plus includes additional reinforcement.
  • Primary outcomes include lipid levels, blood pressure, physical activity, and smoking rates over three years.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • Presents the rationale and design for a multi-center study.
  • Tests a modular approach for secondary prevention of CHD post-ACS.
  • Aims to validate the CHOICE program's replicability and the impact of extended reinforcement.
Abstract

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