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Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

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Related Experiment Videos

Type 2 diabetes does not predict incident thyroid dysfunction in the elderly.

Bamini Gopinath1, Jie Jin Wang, Annette Kifley

  • 1Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, NSW, Australia.

Diabetes Research and Clinical Practice
|October 8, 2008
PubMed
Summary
This summary is machine-generated.

Older adults with type 2 diabetes showed a higher incidence of thyroid dysfunction compared to those without diabetes. However, these findings do not support routine thyroid screening in this population.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Diabetes Research

Background:

  • Type 2 diabetes is a prevalent condition in older adults.
  • Thyroid dysfunction is common in the elderly population.
  • The relationship between type 2 diabetes and thyroid dysfunction in older adults requires further investigation.

Purpose of the Study:

  • To assess the incidence of thyroid dysfunction in an older population-based cohort with type 2 diabetes.
  • To compare the risk of thyroid dysfunction in older adults with and without type 2 diabetes.

Main Methods:

  • A population-based cohort study was conducted.
  • Incident thyroid dysfunction was assessed in older adults.
  • Data were analyzed comparing subjects with and without type 2 diabetes.

Main Results:

  • 7.1% of older adults with type 2 diabetes developed incident thyroid dysfunction.
  • 3.8% of older adults without diabetes developed incident thyroid dysfunction.
  • The odds ratio for incident thyroid dysfunction in type 2 diabetes subjects was 1.97 (95% CI 0.88-4.38).

Conclusions:

  • While a higher incidence of thyroid dysfunction was observed in older adults with type 2 diabetes, the results were not statistically significant.
  • Current findings do not provide sufficient evidence to support routine thyroid dysfunction screening in older individuals with type 2 diabetes.