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Updated: Jun 29, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Pregnancy in systemic sclerosis].

Alice Bérezné¹, Luc Mouthon

¹Faculté de Médecine, UPRES EA 4058, Pôle de Médecine Interne, Centre de Référence Maladies Auto-Immunes Systémiques Rares, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris Cedex 14, France. alice.berezne@cch.aphp.fr

Presse Medicale (Paris, France : 1983)

|October 8, 2008

Summary

Pregnancies in systemic sclerosis (SSc) patients require careful planning. While risks exist, such as preterm birth, planning pregnancies during stable disease phases and multidisciplinary care can improve outcomes.

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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

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Published on: June 13, 2021

Area of Science:

Rheumatology
Obstetrics
Maternal-Fetal Medicine

Context:

Systemic sclerosis (SSc) historically posed high risks for pregnancy outcomes.
Previous studies indicated increased preterm births and small for gestational age infants in SSc pregnancies.
Miscarriage and neonatal survival rates were comparable to healthy controls.

Purpose:

To review the risks and management strategies for pregnancies in patients with systemic sclerosis.
To provide guidance on optimizing maternal and fetal outcomes in SSc pregnancies.

Summary:

Pregnancies in SSc patients carry risks, notably scleroderma renal crisis, managed with ACE inhibitors despite teratogenicity concerns.
Optimal pregnancy timing involves planning during stable disease phases, avoiding conception in rapidly progressing diffuse SSc.
Safe medications include hydroxychloroquine and low-dose steroids; multidisciplinary care is essential for risk minimization.

Impact:

Highlights the importance of planned pregnancies in SSc for improved maternal and fetal well-being.
Emphasizes the critical role of a multidisciplinary approach in managing SSc pregnancies.
Informs clinical practice regarding medication use and disease monitoring during pregnancy in SSc patients.