[Biology of gliomas]

Gliomas are the most common primary brain tumors. Despite the implementation of therapeutic strategies, these tumors remain fatal. The recent advances in the field of stem cell biology, cell signaling, genomics, bio-informatics and genetic model systems have led to a better understanding of gliomas biology. These advances are facilitating the establishment of a more precise, molecular-based, classification of gliomas and are leading to new therapeutic strategies directed against the key molecular events implicated in gliomas oncogenesis.