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Related Concept Videos

Microenvironments01:22

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 29, 2026

Modeling and Imaging 3-Dimensional Collective Cell Invasion
07:08

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Published on: December 7, 2011

Microenvironment driven invasion: a multiscale multimodel investigation.

Alexander R A Anderson1, Katarzyna A Rejniak, Philip Gerlee

  • 1Division of Mathematics, University of Dundee, Dundee, Scotland, UK. Alexander.Anderson@moffitt.org

Journal of Mathematical Biology
|October 8, 2008
PubMed
Summary
This summary is machine-generated.

Aggressive cancer cells invade in nutrient-poor environments, not nutrient-rich ones. Tumor invasion depends on both the tumor

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Area of Science:

  • Computational biology
  • Cancer research
  • Mathematical modeling

Background:

  • Cancer is a multiscale process involving genetic mutations and cellular changes.
  • Tumor microenvironment interactions are critical for tumor progression and suppression.
  • Tumor invasion, characterized by fingering morphology, is linked to harsh microenvironmental conditions.

Purpose of the Study:

  • To investigate the impact of nutrient availability on tumor invasion.
  • To examine how cell metabolism influences tumor growth and invasion.
  • To understand how microenvironmental nutrient changes drive tumor genetic and morphological evolution.

Main Methods:

  • Utilized three distinct computational modeling approaches.
  • Simulations were conducted at two different spatial scales.
  • Focused on nutrient availability as a driver of invasion and analyzed cell metabolism.

Main Results:

  • Aggressive tumor phenotypes resulted in fingering morphology specifically in poor nutrient microenvironments.
  • Tumor invasion was not observed in rich nutrient conditions, even with aggressive phenotypes.
  • Simulation results highlight the co-dependence of invasion on evolutionary dynamics and microenvironment.

Conclusions:

  • Nutrient availability is a key factor modulating tumor invasion.
  • Cell metabolism and resistance to starvation significantly influence tumor morphology and invasion.
  • Tumor invasion is an emergent property driven by the interplay between tumor evolution and microenvironmental conditions.