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Updated: Jun 29, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia
Athanasios Papadopoulos1, George Ntaios2,3, Georgia Kaiafa1
1First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloníki, Greece.
Abstract:
Veno-occlusive disease (VOD) of the liver, also termed as sinusoidal obstruction syndrome, constitutes a well-known complication of high-dose cytoreductive chemotherapy prior to allogeneic or autologous bone marrow transplantation and is associated with the intensity of treatment [1]. On the contrary, there is only one report of VOD during induction therapy for acute lymphoblastic leukemia in a patient with Marfan syndrome, who was successfully treated with defibrotide [2]. In this article, we present the first fatal case of VOD during induction therapy for acute lymphoblastic leukemia.
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