Effects of men and recipients' age on the reproductive outcome of an oocyte donation program

The objective of this study was to evaluate the effect of men and recipient age on the reproductive outcome of our oocyte donation program.

We retrospectively analyzed 915 cycles, taking into account men and recipient age, separately and together.

The significant cut off value for men and recipients age with incidence in the reproductive outcome was 39 years. Recipient older than 38 years presented a significantly lower pregnancy and implantation rates than others (44.92 vs. 55.75 +/- 1.53%, 25.66 vs. 32.79 +/- 1.64%). If men age was older than 38, a significant reduction in pregnancy and implantation rates was observed, too (46.0 vs. 54.65%, 26.00 +/- 1.52 vs. 32.43 +/- 1.65%). When men and recipient age was analyzed together, a reduction in pregnancy and implantation was detected only if both were older than 38.

Present study suggests that age has a detrimental effect on the reproductive outcome of oocyte donation cycles when both men and recipient are > or = 39 years old.