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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Updated: Jun 29, 2026

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

[Meniere's disease in the elderly].

Ziming Wu¹, Suzhen Zhang, Xingjian Liu

¹Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital, Otolaryngology Institute of Chinese PLA, Beijing, 100853, China. zimingwu@163.com

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery

|October 9, 2008

Summary

This study found Meniere's disease in the elderly affects 2.22% of patients, with initial symptoms including hearing loss and vertigo. Audiograms revealed high-frequency hearing loss, and electrocochleography (ECoG) showed a high positive result rate.

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In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

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Last Updated: Jun 29, 2026

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

Area of Science:

Otolaryngology
Neurology
Geriatrics

Context:

Meniere's disease is a rare inner ear disorder.
Prevalence and clinical characteristics in the elderly population are not well-documented.

Purpose:

To determine the prevalence of Meniere's disease in individuals aged 60 and above.
To investigate the clinical manifestations and diagnostic test results in elderly patients with Meniere's disease.

Summary:

A study observed 13 elderly patients diagnosed with Meniere's disease between 2004 and 2007.
The overall prevalence was 2.22%. Initial symptoms included cochlear and/or vestibular issues, vertigo, or drop attacks.
Audiometry indicated varied hearing loss patterns, predominantly high-frequency loss unrelated to disease duration. Vestibular function tests yielded diverse results, with electrocochleography (ECoG) showing a 63.6% positive rate.

Impact:

This research highlights the prevalence and specific clinical features of Meniere's disease in the elderly.
Findings contribute to a better understanding of the condition in this demographic, aiding in diagnosis and management.
The study underscores the utility of ECoG in diagnosing Meniere's disease in older adults.