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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Published on: February 7, 2021

Hydrogel nanoparticles in drug delivery.

Mehrdad Hamidi1, Amir Azadi, Pedram Rafiei

  • 1Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran. hamidim@sums.ac.ir

Advanced Drug Delivery Reviews
|October 9, 2008
PubMed
Summary

Hydrogel nanoparticles, combining hydrogel and nanoparticle properties, show promise for drug delivery. Their release mechanisms are complex, influenced by polymer type and crosslinking methods.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Hydrogel nanoparticles are emerging as advanced drug delivery systems.
  • They combine hydrogel properties (hydrophilicity, high water content) with nanoparticle characteristics (small size).
  • Both natural (chitosan, alginate) and synthetic polymers (PVA, PEO, PEI, PVP, PNIPAM) are used.

Purpose of the Study:

  • To review the preparation and characteristics of polymeric hydrogel nanoparticles for drug delivery.
  • To discuss the complex drug release mechanisms from these systems.
  • To categorize the crosslinking methods used in hydrogel nanoparticle formation.

Main Methods:

  • Literature review of hydrogel nanoparticle preparation and characterization.
  • Analysis of drug release kinetics from various hydrogel nanoparticle systems.
  • Classification of crosslinking techniques (chemical and physical).

Main Results:

  • Hydrogel nanoparticles offer unique advantages for drug delivery due to their hybrid nature.
  • Drug release is governed by diffusion, swelling, and matrix-drug interactions.
  • Various natural and synthetic polymers enable tailored hydrogel nanoparticle properties.
  • Both chemical and physical crosslinking methods are employed to form hydrogel matrices.

Conclusions:

  • Polymeric hydrogel nanoparticles represent a versatile platform for drug delivery.
  • Understanding release mechanisms and crosslinking is crucial for optimizing their performance.
  • Continued research into novel polymers and crosslinking strategies will enhance their therapeutic potential.