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High-sensitivity C-reactive protein is not independently associated with peripheral subclinical atherosclerosis

Mario Bo1, Laura Corsinovi, Alessia Brescianini

  • 1SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Corso Bramante 88, Turin, Italy. mario.bo@unito.it

Angiology
|October 9, 2008
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) is linked to peripheral atherosclerosis severity in at-risk individuals. However, this association is not independent of traditional cardiovascular risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation.
  • Subclinical peripheral atherosclerosis involves early arterial changes.
  • The independent predictive value of hs-CRP for atherosclerosis requires further investigation.

Purpose of the Study:

  • To determine if hs-CRP levels are independently associated with subclinical peripheral atherosclerosis.
  • To evaluate the relationship between hs-CRP and measures of atherosclerosis like ABI and cIMT.

Main Methods:

  • A cohort of 320 subjects without prior cardiovascular disease was studied.
  • Clinical variables, cardiovascular risk factors, and 10-year CV risk were assessed.
  • Ankle-brachial Index (ABI) and carotid intima-media thickness (cIMT) were measured.

Main Results:

  • hs-CRP levels correlated with cardiovascular risk factors, 10-year CV risk, lower ABI, and higher cIMT.
  • After adjusting for covariates, hs-CRP associations with ABI and cIMT were not statistically significant.

Conclusions:

  • hs-CRP levels are associated with peripheral atherosclerosis severity in asymptomatic individuals.
  • These associations are not independent of traditional cardiovascular risk factors.
  • hs-CRP may have a limited independent predictive role for subclinical atherosclerosis.
Abstract

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