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Updated: Jun 29, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Lkb1 is required for TGFbeta-mediated myofibroblast differentiation

Kari Vaahtomeri1, Eeva Ventelä, Kaisa Laajanen

  • 1Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, 00014 University of Helsinki, Finland.

Journal of Cell Science
|October 9, 2008
PubMed
Summary

Loss of the tumor suppressor LKB1 (liver kinase B1) in mesenchymal cells impairs TGF-beta signaling, leading to defective myofibroblast differentiation and potentially contributing to Peutz-Jeghers syndrome (PJS) tumorigenesis.

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