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Updated: Jun 29, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
Published on: December 1, 2023
Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth
Melissa Shaw1, Mary Savoye, Anna Cali
1Department of Pediatrics, Yale University, New Haven, Connecticut, USA. melissa.m.shaw@yale.edu
Objective:
To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.
Research Design And Methods:
Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.
Results:
Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).
Conclusions:
An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
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