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Effect of fluoroquinolones on body temperature of mice
Shuichi Miyazaki1, Fumio Ishikawa, Saburo Matsuo
1Department of Microbiology and Infectious Disease, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan. shuichi@med.toho-u.ac.jp
The Journal of Antimicrobial Chemotherapy
|October 9, 2008
Summary
Fluoroquinolones, a class of antibiotics, were found to lower rectal temperature in mice, irrespective of infection status. This hypothermic effect was observed in both infected and non-infected animals.
Area of Science:
- Pharmacology
- Microbiology
- Animal Models
Background:
- Antibiotics are crucial for treating bacterial infections.
- Understanding drug side effects is vital for patient safety.
- Fever is a common symptom of infection, but drug-induced hypothermia is a potential concern.
Purpose of the Study:
- To evaluate the impact of fluoroquinolones on mouse rectal temperature.
- To determine if infection influences the hypothermic effect of fluoroquinolones.
- To compare the effects of fluoroquinolones with cephems on body temperature.
Main Methods:
- A mouse model was utilized to study drug effects.
- Rectal temperature was monitored after administration of fluoroquinolones (gatifloxacin) and cephems (cefditoren pivoxil).
- Experiments were conducted on both infected and non-infected mice.
Main Results:
- Gatifloxacin induced hypothermia in non-infected mice at doses of 1 and 10 mg/kg.
- Cefditoren pivoxil did not cause hypothermia in non-infected mice.
- Both fluoroquinolones and cephems decreased rectal temperature in infected mice, with fluoroquinolones causing a more significant reduction.
Conclusions:
- Fluoroquinolones demonstrably decrease rectal temperature in mice.
- This hypothermic effect occurs independently of the presence of infection.
- Fluoroquinolones exhibit a more pronounced hypothermic effect compared to cephems in infected mice.
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