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Updated: Jun 29, 2026
08:39
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Pulse push/pull hemodialysis in a canine renal failure model.
Kyungsoo Lee1, Byoung Goo Min, Cho Hae Mun
1Bio Heart & Kidney (BHK) Inc., Seoul, Korea. jake0902@snu.ac.kr
Blood Purification
|October 9, 2008
Summary
A novel hemodialysis method using out-of-phase pulsatile flow enhances convective mass transfer. This new dialysis modality safely improved urea and creatinine clearance while preserving membrane integrity in a canine model.
Area of Science:
- Nephrology
- Biomedical Engineering
- Fluid Dynamics
Background:
- Conventional hemodialysis faces limitations in convective mass transfer efficiency.
- Optimizing fluid dynamics in dialysis can potentially improve solute removal and membrane performance.
Purpose of the Study:
- To investigate the hemodialytic performance of a newly devised modality utilizing out-of-phase pulsatile blood and dialysate flow.
- To compare the effects of the new modality on membrane hydraulic permeability (K(uf)) and fiber bundle volume (FBV) against conventional high-flux hemodialysis.
Main Methods:
- A canine renal failure model was employed to test the new dialysis modality.
- Blood and dialysate were circulated using a pulsatile pump with flow patterns 180 degrees out of phase.
- Hemodynamic performance was assessed by measuring postdialysis K(uf) and FBV, and comparing them to conventional hemodialysis.
Main Results:
- The new modality demonstrated satisfactory urea and creatinine reduction without complications.
- Postdialysis K(uf) and FBV were significantly reduced after both dialysis types, but remained higher with the new modality.
- The oscillating pressure gradients generated by the out-of-phase flow did not cause technical issues or adverse effects in the canine subjects.
Conclusions:
- The devised pulsatile hemodialysis modality is a safe and effective method for enhancing convective mass transfer.
- This innovative approach offers a promising alternative to conventional hemodialysis, potentially improving patient outcomes through better solute clearance and preserved membrane function.
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