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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 29, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Sequential Ewing's sarcoma and osteosarcoma.

Vivek Sharma¹, Alvin H Crawford, Jonathan Evans

¹Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55454, USA. vivorth227@yahoo.com

Journal of Pediatric Orthopedics. Part B

|October 9, 2008

Summary

This summary is machine-generated.

A rare case of a 12-year-old boy developed two distinct primary bone tumors, Ewing's sarcoma and osteosarcoma, years apart. This patient also presented with a rare genetic translocation, t(7;22).

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Area of Science:

Oncology
Genetics
Orthopedic Oncology

Background:

The occurrence of multiple primary bone tumors in a single patient is uncommon.
Ewing's sarcoma and osteosarcoma are distinct bone malignancies with different origins and characteristics.

Observation:

A 12-year-old male patient was diagnosed with Ewing's sarcoma of the proximal fibula.
Five years after initial treatment, the same patient developed a high-grade fibroblastic osteosarcoma in the proximal humerus.

Findings:

The patient exhibited a rare chromosomal translocation, t(7;22), instead of the typically observed t(11;22) associated with Ewing's sarcoma.
This case represents a sequential occurrence of two primary bone tumors at different sites.

Implications:

This case highlights the importance of considering rare genetic factors in the development of multiple primary bone tumors.
Further research into the genetic underpinnings of sequential bone malignancies may reveal novel therapeutic targets.
Understanding rare gene translocations could improve diagnostic accuracy and prognostic assessment in pediatric bone cancers.