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Updated: Jun 29, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
Sequential Ewing's sarcoma and osteosarcoma
Vivek Sharma1, Alvin H Crawford, Jonathan Evans
1Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55454, USA. vivorth227@yahoo.com
Abstract:
The sequential occurrence of two primary bone tumors, Ewing's sarcoma and osteosarcoma in the same patient at two different anatomical sites 5 years apart is rare. We report a case of 12-year-old boy who after treatment for Ewing's sarcoma of proximal fibula subsequently presented, 4 years later, with a high-grade fibroblastic osteosarcoma of the proximal humerus. The patient was also found to have a rare gene tranlocation t (7;22) instead of the more common t (11;22).
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