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Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial
Michiel H Strijbos1, Chandra Rao, Paul I M Schmitz
1Erasmus University Medical Center-Daniel den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam, The Netherlands. m.strijbos@erasmusmc.nl
Circulating endothelial cells (CEC) correlate with thrombomodulin levels, a marker of vascular damage. CEC numbers increase with age, but biomarker levels do not, though males show higher thrombomodulin and E-selectin.
Area of Science:
- Vascular Biology
- Biomarker Discovery
- Oncology
Background:
- Circulating endothelial cells (CEC) indicate vascular damage in various diseases.
- Soluble markers of endothelial injury, activation, and proliferation are being investigated.
Purpose of the Study:
- To assess the correlation between CEC counts and soluble endothelial markers.
- To explore factors influencing CEC numbers and biomarker levels.
Main Methods:
- Automated CD146 immunomagnetic isolation for CEC enumeration.
- ELISA for plasma E-selectin, endoglin, and thrombomodulin quantification.
- Study included 125 healthy donors and 40 cancer patients.
Main Results:
- CEC numbers positively correlated with plasma thrombomodulin levels.
- No significant correlation found between CEC and E-selectin or endoglin.
- CEC counts increased significantly with age; biomarker levels were age-independent.
- Males exhibited higher thrombomodulin and E-selectin levels than females.
Conclusions:
- CEC counts are positively associated with plasma thrombomodulin levels.
- Age is a significant factor influencing CEC numbers.
- Sex influences levels of certain endothelial biomarkers.
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