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Updated: Jun 29, 2026
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
[Aquaporin 1 expression in invasive breast carcinomas]
F Otterbach1, R Callies, R Kimmig
1Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen. friedrich.otterbach@uk-essen.de
Der Pathologe
|October 9, 2008
Summary
Aquaporin1 (AQP1) is a water channel protein. Its expression in invasive breast cancer correlates with aggressive features and predicts a poorer prognosis, independent of other factors.
Area of Science:
- Molecular Biology
- Oncology
- Cell Biology
Context:
- Aquaporin1 (AQP1) facilitates water transport across cell membranes.
- AQP1 is increasingly implicated in tumor angiogenesis, migration, and metastasis.
- Understanding AQP1's role in breast cancer is crucial for prognosis.
Purpose:
- To investigate the immunohistochemical expression of AQP1 in invasive breast carcinomas.
- To correlate AQP1 expression with clinicopathological features and patient outcomes.
Summary:
- AQP1 expression was detected in 5.4% of 203 invasive breast carcinomas.
- AQP1 correlated with high tumor grade, medullary-like histology, triple-negativity, cytokeratin 14, and actin expression.
- Univariate and multivariate analyses confirmed AQP1 as an independent predictor of poor prognosis.
Impact:
- AQP1 expression is associated with a basal-like phenotype in breast cancer.
- Identifies AQP1 as a potential biomarker for aggressive breast cancer subtypes.
- Highlights AQP1's role in predicting patient outcome and informing treatment strategies.
